Aldehyde dehydrogenase is blocked by the drug disulfiram, also known as Antabuse, which is sometimes used to help alcoholics quit the habit. "But you have to take it every day, so there is a big problem with compliance," says Amalia Sapag at the University of Chile in Santiago.
To provide a longer-lasting effect, Sapag's team engineered adenoviruses to carry an "antisense" version of the aldehyde dehydrogenase gene. This produces RNA that binds to the original gene's messenger RNA, blocking enzyme production.
A single injection of viruses reduced the enzyme's activity in rats' livers by 80 per cent, Sapag revealed at the American Society of Gene Therapy meeting in Seattle earlier this month.
Saturday, June 23, 2007
Gene Therapy for Alcoholism?
A new study suggests gene therapy can help curb alcoholism by manipulating a gene responsible for the metabolism of alcohol:
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